Article
BRCA1 interacts with FHL2 and enhances FHL2 transactivation function.
FEBS letters - 9 Oct 2003
Yan Jinghua, Zhu Jianhua, Zhong Hongjun, Lu Qiujun, Huang Cuifen, Ye Qinong
Abstract excerpt
Germ-line mutations in BRCA1 are associated with an increased lifetime risk of developing breast and/or ovarian tumors. The BRCA1 gene product is a 220-kDa protein that contains a tandem of two BRCA1 C-terminal (BRCT) domains required for transcription. In an attempt to understand how BRCA1 exerts its function through BRCT domains, we search for partners of the BRCT domains of BRCA1. Using the yeast two-hybrid...
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