Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects on human transcriptome of mutated BRCA1 BRCT domain: a microarray study.

BMC cancer - 30 May 2012

Iofrida Caterina, Melissari Erika, Mariotti Veronica, Guglielmi Chiara, Guidugli Lucia, Caligo Maria Adelaide, Pellegrini Silvia

Abstract excerpt

BACKGROUND: BRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but the role of these variants in cancer predisposition is often difficult to ascertain. In this work, the molecular mechanisms affected in human cells by two BRCA1 missense variants, M1775R and A1789T, both located in the second BRCT (BRCA1 C Terminus) domain, have been investigated....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Genomic Instability

Share to HeLa Cells

Share to Protein Interaction Domains and Motifs

Share to Reproducibility of Results

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 22646717
DOI: 10.1186/1471-2407-12-207
PMCID: PMC3489683

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects on human transcriptome of mutated BRCA1 BRCT domain: a microarray study.PMID 22646717Read ↗

Missense mutations of BRCA1 gene affect the binding with p53 both in vitro and in vivo.Semantic proximity Read ↗

[Mapping of BRCT1 domain of BRCA1 with chromatin unfolding activity].Semantic proximity Read ↗

Insights into the molecular basis of human hereditary breast cancer from studies of the BRCA1 BRCT domain.Semantic proximity Read ↗

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.Semantic proximity Read ↗

A novel domain of BRCA1 interacts with p53 in breast cancer cells.Semantic proximity Read ↗

A high-throughput functional complementation assay for classification of BRCA1 missense variants.Semantic proximity Read ↗

BRCA1 transcriptionally regulates genes involved in breast tumorigenesis.Semantic proximity Read ↗

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.Semantic proximity Read ↗

Specific changes in the proteomic pattern produced by the BRCA1-Ser1841Asn missense mutation.Semantic proximity Read ↗

Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.Semantic proximity Read ↗

Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition.Semantic proximity Read ↗

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.