Article
BRCA1 physically and functionally interacts with ATF1.
The Journal of biological chemistry - 17 Nov 2000
Houvras Y, Benezra M, Zhang H, Manfredi J J, Weber B L, Licht J D
Abstract excerpt
BRCA1, a breast and ovarian cancer susceptibility gene, encodes a 220-kDa protein whose precise biochemical function remains unclear. BRCA1 contains an N-terminal RING finger that mediates protein-protein interaction. The C-terminal domain of BRCA1 (BRCT) can activate transcription and interacts with RNA polymerase holoenzyme. Using the yeast two-hybrid system, we identified an interaction between the BRCA1 RING...
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