Article
Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.
The EMBO journal - 2 Nov 1998
Zhang X, Moréra S, Bates P A, Whitehead P C, Coffer A I, Hainbucher K, Nash R A, Sternberg M J, Lindahl T, Freemont P S
Abstract excerpt
The BRCT domain (BRCA1 C-terminus), first identified in the breast cancer suppressor protein BRCA1, is an evolutionarily conserved protein-protein interaction region of approximately 95 amino acids found in a large number of proteins involved in DNA repair, recombination and cell cycle control. H...
Topics
- Amino Acid Sequence
- BRCA1 Protein
- Conserved Sequence
- Crystallography, X-Ray
- DNA-Binding Proteins
- Dimerization
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Sequence Alignment
- X-ray Repair Cross Complementing Protein 1