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Article

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.

The EMBO journal - 2 Nov 1998

Zhang X, Moréra S, Bates P A, Whitehead P C, Coffer A I, Hainbucher K, Nash R A, Sternberg M J, Lindahl T, Freemont P S

Abstract excerpt

The BRCT domain (BRCA1 C-terminus), first identified in the breast cancer suppressor protein BRCA1, is an evolutionarily conserved protein-protein interaction region of approximately 95 amino acids found in a large number of proteins involved in DNA repair, recombination and cell cycle control. Here we describe the first three-dimensional structure and fold of a BRCT domain determined by X-ray crystallography at...

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Source

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Identifiers

PMID: 9799248
DOI: 10.1093/emboj/17.21.6404
PMCID: PMC1170965

Genes

XRCC1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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