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Article

[Mapping of BRCT1 domain of BRCA1 with chromatin unfolding activity].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Nov 2002

Ye Qi-Nong, Hu Yan-Fen, Zhong Hong-Jun, Li Rong, Huang Cui-Fen

Abstract excerpt

Breast cancer susceptibility gene 1(BRCA1) plays an important role in breast cancer development and progression. BRCA1 encodes a 1863-amino acid protein with two BRCA1 C-terminal (BRCT) domains at its C-terminus, BRCT1 and BRCT2. Many cancer-predisposing mutations are located in the BRCT domains, which have been shown to induce chromatin unfolding by use of an approach that allows visualization of large-scale...

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Identifiers

PMID: 12674632

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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