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Article

Inducible expression of dominant negative insulin-like growth factor I receptor in MCF-7 breast cancer cells.

Endocrine - 1 Dec 2003

Modha Geetanjalee, Blanchard Anne, Sidorchuk Janine, Venditti Marcello, Shiu Robert, Myal Yvonne

Abstract excerpt

The insulin-like growth factor I receptor (IGF-IR) is expressed in many cell types and is critical for normal growth and development. In the healthy mammary gland, the role of IGF-IR is not fully elucidated. However, IGF-IR, which is primarily expressed in the mammary epithelial cells, is known to play an obligatory role in cellular transformation, facilitating the progression to breast cancer. We have utilized...

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PMID: 14709803
DOI: 10.1385/ENDO:22:3:293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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