Article
A new type of E. coli recombinational hotspot which requires for activity both DNA replication termination events and the Chi sequence.
Advances in biophysics - 1 Jan 1995
Horiuchi T, Nishitani H, Kobayashi T
Abstract excerpt
In E. coli rnh- mutants we identified chromosome-derived, specific DNA fragments termed Hot DNA. When the DNA in the ccc form is integrated into the E. coli genome by homologous recombination to form a directly repeated structure, a striking enhancement of excisional recombination between the repeats occurs. We obtained 8 groups of such Hot DNA, 7 of which were clustered in a narrow region called the replication...
Topics
- Base Sequence
- Biophysical Phenomena
- Biophysics
- Chromosome Mapping
- DNA Replication
- DNA, Bacterial
- Escherichia coli
- Genes, Bacterial
- Genes, Fungal
- Models, Genetic
- Mutation