Article
On the mechanism of gene amplification induced under stress in Escherichia coli.
PLoS genetics - 1 Apr 2006
Slack Andrew, Thornton P C, Magner Daniel B, Rosenberg Susan M, Hastings P J
Abstract excerpt
Gene amplification is a collection of processes whereby a DNA segment is reiterated to multiple copies per genome. It is important in carcinogenesis and resistance to chemotherapeutic agents, and can underlie adaptive evolution via increased expression of an amplified gene, evolution of new gene functions, and genome evolution. Though first described in the model organism Escherichia coli in the early 1960s, only...
Topics
- Base Sequence
- DNA
- DNA Damage
- DNA Repair
- Escherichia coli
- Escherichia coli Proteins
- Gene Amplification
- Genes, Bacterial
- Genomics
- Molecular Sequence Data
- Mutation