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Article

The unfolding of the prion protein sheds light on the mechanisms of prion susceptibility and species barrier.

Biochemistry - 15 Sept 2009

Robinson Philip J, Pinheiro Teresa J T

Abstract excerpt

Prion diseases are a group of fatal neurodegenerative disorders that manifest as infectious, sporadic, or familial and are all associated with the misfolding of the prion protein (PrP). Disease-modulating polymorphisms in the PrP amino acid sequence can make an individual more or less susceptible to infection. One example is the presence of arginine in place of glutamine at position 171 in sheep, which confers...

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PMID: 19655812
DOI: 10.1021/bi901070t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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