Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.

Journal of virology - 1 Jul 2007

Vaccari Gabriele, D'Agostino Claudia, Nonno Romolo, Rosone Francesca, Conte Michela, Di Bari Michele Angelo, Chiappini Barbara, Esposito Elena, De Grossi Luigi, Giordani Francesco, Marcon Stefano, Morelli Luisella, Borroni Renata, Agrimi Umberto

Abstract excerpt

The susceptibility of sheep to classical scrapie and bovine spongiform encephalopathy (BSE) is mainly influenced by prion protein (PrP) polymorphisms A136V, R154H, and Q171R, with the ARR allele associated with significantly decreased susceptibility. Here we report the protective effect of the amino acid substitution M137T, I142K, or N176K on the ARQ allele in sheep experimentally challenged with either scrapie...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Cattle

Share to Encephalopathy, Bovine Spongiform

Share to Prions

Share to Scrapie

Source

Open in PubMed Open full text

Identifiers

PMID: 17442723
DOI: 10.1128/JVI.02880-06
PMCID: PMC1933282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.PMID 17442723Read ↗

Protective effect of the AT137RQ and ARQK176 PrP allele against classical scrapie in Sarda breed sheep.Semantic proximity Read ↗

Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France.Semantic proximity Read ↗

Ovine prion protein variant A(136)R(154)L(168)Q(171) increases resistance to experimental challenge with bovine spongiform encephalopathy agent.Semantic proximity Read ↗

p.Asn176Lys and p.Met137Thr dimorphisms of the PRNP gene significantly decrease the susceptibility to classical scrapie in ARQ/ARQ sheep.Semantic proximity Read ↗

Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep.Semantic proximity Read ↗

The PrP(C) C1 fragment derived from the ovine A136R154R171PRNP allele is highly abundant in sheep brain and inhibits fibrillisation of full-length PrP(C) protein in vitro.Semantic proximity Read ↗

Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants.Semantic proximity Read ↗

Prion protein allele A136 H154Q171 is associated with high susceptibility to scrapie in purebred and crossbred German Merinoland sheep.Semantic proximity Read ↗

Amyloidogenic unfolding intermediates differentiate sheep prion protein variants.Semantic proximity Read ↗

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.Semantic proximity Read ↗

Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep.Semantic proximity Read ↗

Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.