Article
Ovine prion protein variant A(136)R(154)L(168)Q(171) increases resistance to experimental challenge with bovine spongiform encephalopathy agent.
The Journal of general virology - 1 Dec 2006
Goldmann Wilfred, Houston Fiona, Stewart Paula, Perucchini Matteo, Foster James, Hunter Nora
Abstract excerpt
Susceptibility and incubation periods of transmissible spongiform encephalopathies, such as scrapie in sheep, are modulated by the PrP gene. The standard model of association between ovine PrP genetics and classical scrapie susceptibility is based on PrP genotypes with respect to codons 136, 154 and 171, e.g. alanine-arginine-glutamine (ARQ). It is demonstrated here that a proline to leucine substitution in codon...
Topics
- Alleles
- Amino Acid Substitution
- Animals
- Cattle
- Disease Models, Animal
- Disease Susceptibility
- Encephalopathy, Bovine Spongiform
- Genotype
- Heterozygote
- Immunity, Innate
- Polymorphism, Genetic
- Prion Diseases
- Prions
- Sheep