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Article

Conformational polymorphism of wild-type and mutant prion proteins: Energy landscape analysis.

Proteins - 1 Jun 2002

Levy Yaakov, Becker Oren M

Abstract excerpt

Conformational transitions are thought to be the prime mechanism of prion diseases. In this study, the energy landscapes of a wild-type prion protein (PrP) and the D178N and E200K mutant proteins were mapped, enabling the characterization of the normal isoforms (PrP(C)) and partially unfolded isoforms (PrP(PU)) of the three prion protein analogs. It was found that the three energy landscapes differ in three...

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Identifiers

PMID: 12001224
DOI: 10.1002/prot.10095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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