Article
Tumor spectrum in the p53 heterozygous zeta globin-promoted Tg.AC (v-Ha-ras) bitransgenic mouse model.
Toxicologic pathology - 1 Jan 2000
Martin Keith R, Jokinen Michael P, Honeycutt Hayden P, Quinn Anita, Kari Frank W, Barrett J Carl, French John E
Abstract excerpt
The use of a bitransgenic mouse model for cancer is an effective approach for studying the impact of specific carcinogens and the occurrence of tissue-specific lesions. We studied the novel p53 heterozygous zeta globin-promoted Tg.AC (v-Ha-ras) mouse model because these mice contain a carcinogen-inducible ras oncogene and one functional p53 tumor suppressor allele, both of which occur frequently in human cancers....
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