Article
Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.
Oncogene - 1 Aug 1990
Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M
Abstract excerpt
Two independent transgenic mouse lines carrying human hybrid c-Ha-ras genes with their own promoter region encoding prototype products, were established. In these lines, about 50% of transgenic offspring had tumors within 18 months. The tumors developed in restricted tissues and about 60% of affe...
Topics
- Animals
- Codon
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Mice
- Mice, Transgenic
- Mutation
- Neoplasms, Experimental
- RNA, Messenger