Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional and Posttranscriptional Regulation of Cyclooxygenase-2 Expression by Fluid Shear Stress in Vascular Endothelial Cells

1 Sept 2002

Abstract excerpt

OBJECTIVE: Fluid shear stress induces cyclooxygenase (COX)-2 gene expression in vascular endothelial cells. We investigated the underlying mechanism of this induction. METHODS AND RESULTS: Exposure of human umbilical vein endothelial cells to laminar shear stress in the physiological range (1 to 30 dyne/cm2) upregulated the expression of COX-2 but not COX-1, a constitutive isozyme of COX. The expression of COX-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connective Tissue Growth Factor Research
Share to Inflammatory mediators and NSAID effects
Share to Nitric Oxide and Endothelin Effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12231559
DOI: 10.1161/01.atv.0000028816.13582.13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional and Posttranscriptional Regulation of Cyclooxygenase-2 Expression by Fluid Shear Stress in Vascular Endothelial CellsPMID 12231559Read ↗

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region.Semantic proximity Read ↗

Fluid Shear Stress Modulation of Gene Expression in Endothelial CellsSemantic proximity Read ↗

Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells.Semantic proximity Read ↗

Global Analysis of Shear Stress-Responsive Genes in Vascular Endothelial CellsSemantic proximity Read ↗

Evidence for modulation of genes involved in vascular adaptation by prolonged exposure of endothelial cells to shear stressSemantic proximity Read ↗

Systems biology analysis of longitudinal functional response of endothelial cells to shear stressSemantic proximity Read ↗

Influence of a GT repeat element on shear stress responsiveness of the VWF gene promoter.Semantic proximity Read ↗

Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications.Semantic proximity Read ↗

Egr-1 is Activated in Endothelial Cells Exposed to Fluid Shear Stress and Interacts With a Novel Shear-Stress-Response Element in the PDGF A-Chain PromoterSemantic proximity Read ↗

DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cellsSemantic proximity Read ↗

Gene expression profile of human endothelial cells exposed to sustained fluid shear stress.Semantic proximity Read ↗

Control of endothelial cell gene expression by flow.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.