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Article

Influence of a GT repeat element on shear stress responsiveness of the VWF gene promoter.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2008

Hough C, Cameron C L, Notley C R P, Brown C, O'Brien L, Keightley A M, Berber E, Lillicrap D

Abstract excerpt

BACKGROUND: Plasma von Willebrand factor (VWF) is mainly derived from endothelial cells, cells that express a large repertoire of genes that are transcriptionally regulated by fluid shear stress. Endothelial VWF expression is not uniform throughout the vasculature, and levels are increased at regions associated with disturbed blood flow and steep gradients of shear stress. It is, however, unknown whether shear...

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Source

Identifiers

PMID: 18485092
DOI: 10.1111/j.1538-7836.2008.03011.x

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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