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DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells

31 Jul 2001

Abstract excerpt

Using DNA microarray screening (GeneFilter 211, Research Genetics, Huntsville, AL) of mRNA from primary human umbilical vein endothelial cells (HUVEC), we identified 52 genes with significantly altered expression under shear stress [25 dynes/cm(2) for 6 or 24 h (1 dyne = 10 microN), compared with matched stationary controls]; including several genes not heretofore recognized to be shear stress responsive. We...

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PMID: 11481467
DOI: 10.1073/pnas.171259298

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