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Article

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region.

Biological chemistry - 1 Aug 2004

Huddleson Justin P, Srinivasan Seetha, Ahmad Nisar, Lingrel Jerry B

Abstract excerpt

Fluid shear stress is crucial for maintenance of a properly functioning endothelium. In this study we demonstrate that the KLF2 transcription factor is greatly induced by pulsatile shear stress in murine microvascular endothelial cells. The promoter elements responsible for the induction were studied by transfection with luciferase-reporter plasmids including the 5' flanking region of the murine KLF2 gene....

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Source

Identifiers

PMID: 15449708
DOI: 10.1515/BC.2004.088

Genes

KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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