Article
Bleomycin sensitivity of mice expressing dominant-negative p53 in the lung epithelium.
American journal of respiratory and critical care medicine - 15 Sept 2002
Ghosh Sushmita, Mendoza Tamra, Ortiz Luis A, Hoyle Gary W, Fermin Cesar D, Brody Arnold R, Friedman Mitchell, Morris Gilbert F
Abstract excerpt
The chemotherapeutic drug bleomycin causes DNA damage and apoptosis in the lungs of mice within hours of endotracheal instillation followed by inflammation and fibrosis weeks later. The p53 tumor suppressor protein mediates cellular responses to DNA damage, including induction of apoptosis, but the effects of p53 activation in the various cell types of the lung during bleomycin-induced pulmonary fibrosis remain...
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