Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury.

American journal of respiratory cell and molecular biology - 1 May 2020

Dorry Samuel J, Ansbro Brandon O, Ornitz David M, Mutlu Gökhan M, Guzy Robert D

Abstract excerpt

Alveolar epithelial cell (AEC) injury is central to the pathogenesis of pulmonary fibrosis. Epithelial FGF (fibroblast growth factor) signaling is essential for recovery from hyperoxia- and influenza-induced lung injury, and treatment with FGFs is protective in experimental lung injury. The cell types involved in the protective effect of FGFs are not known. We hypothesized that FGF signaling in type II AECs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bleomycin
Share to Cell Lineage
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Injury

Share to Organ Specificity

Share to Pulmonary Alveoli

Share to Pulmonary Surfactant-Associated Protein C

Share to Receptor, Fibroblast Growth Factor, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 31860803
DOI: 10.1165/rcmb.2019-0079OC
PMCID: PMC7193788

Genes

FGFR2
ACTA2
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury.PMID 31860803Read ↗

Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.Semantic proximity Read ↗

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transitionSemantic proximity Read ↗

Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair.Semantic proximity Read ↗

Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features.Semantic proximity Read ↗

Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosisSemantic proximity Read ↗

Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosisSemantic proximity Read ↗

Type 2 alveolar cells are stem cells in adult lungSemantic proximity Read ↗

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasiaSemantic proximity Read ↗

CREPT is required for pulmonary fibrosis induced by bleomycinSemantic proximity Read ↗

FGFR2 is required for airway basal cell self-renewal and terminal differentiationSemantic proximity Read ↗

Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis.Semantic proximity Read ↗

Epithelial Expression of an Interstitial Lung Disease–Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.