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Article

Transforming growth factor-alpha deficiency reduces pulmonary fibrosis in transgenic mice.

American journal of respiratory cell and molecular biology - 1 May 1999

Madtes D K, Elston A L, Hackman R C, Dunn A R, Clark J G

Abstract excerpt

Despite evidence that implicates transforming growth factor-alpha (TGF-alpha) in the pathogenesis of acute lung injury, the contribution of TGF-alpha to the fibroproliferative response is unknown. To determine whether the development of pulmonary fibrosis depends on TGF-alpha, we induced lung injury with bleomycin in TGF-alpha null-mutation transgenic mice and wild-type mice. Lung hydroxyproline content was 1.3,...

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Source

Identifiers

PMID: 10226062
DOI: 10.1165/ajrcmb.20.5.3526

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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