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Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51

22 Apr 2024

Abstract excerpt

BACKGROUND: Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a key factor in the development of lung pathology. Understanding the mechanisms for bleomycin-induced lung injury is crucial for mitigating its adverse effects. METHODS: Human lung epithelial...

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Share to DNA Repair Mechanisms
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 38649802
DOI: 10.1186/s10020-024-00821-y

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