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Article

Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Nov 2013

Aoshiba Kazutetsu, Tsuji Takao, Kameyama Shinkichi, Itoh Masayuki, Semba Seitaro, Yamaguchi Kazuhiro, Nakamura Hiroyuki

Abstract excerpt

Bleomycin produces DNA damage, apoptosis and senescence, all of which play crucial roles in the development of pulmonary fibrosis. Recently, close attention has been paid to a DNA damage-induced phenotypic change (senescence-associated secretory phenotype; SASP) as a trigger for the secretion of various mediators which modify the processes of tissue injury, inflammation, repair and fibrosis. We characterized the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23688655
DOI: 10.1016/j.etp.2013.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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