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Article

Lack of Transcription Factor p53 Exacerbates Elastase-Induced Emphysema in Mice.

American journal of respiratory cell and molecular biology - 1 Feb 2016

Chrusciel Sandra, Zysman Maéva, Caramelle Philippe, Tiendrebeogo Arnaud, Baskara Indoumady, Le Gouvello Sabine, Chabot François, Giraudier Stéphane, Boczkowski Jorge, Boyer Laurent

Abstract excerpt

The transcription factor p53 is overexpressed in the lung of patients with emphysema, but it remains unclear if it has a deleterious or protective effect in disease progression. We investigated the role of p53 in the elastase-induced emphysema model and the molecular underlining mechanisms. Wild-...

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Source

Identifiers

PMID: 26106979
DOI: 10.1165/rcmb.2014-0375OC

Genes

CCL2
MMP12
TNF
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26106979-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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