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Article

Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancer.

American journal of respiratory cell and molecular biology - 1 Aug 2002

Tchou-Wong Kam-Meng, Jiang Yixing, Yee Herman, LaRosa Jennifer, Lee Theodore C, Pellicer Angel, Jagirdar Jaishree, Gordon Terry, Goldberg Judith D, Rom William N

Abstract excerpt

Mutations in the p53 gene have been implicated to play an important role in the development of various human cancers. To evaluate the importance of p53 in lung cancer, a transgenic mouse model was established by utilizing the Clara cell secretory protein (CCSP) promoter to target the expression of a dominant-negative mutant form of p53 (dnp53) in the lung. In two transgenic CCSP-dnp53 founder lines, the dnp53...

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PMID: 12151310
DOI: 10.1165/ajrcmb.27.2.4799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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