Article
Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke.
Cancer research - 15 Feb 2003
De Flora Silvio, Balansky Roumen M, D'Agostini Francesco, Izzotti Alberto, Camoirano Anna, Bennicelli Carlo, Zhang Zhongqiu, Wang Yian, Lubet Ronald A, You Ming
Abstract excerpt
Mutations and deletions in p53 are the most common genetic lesions in human cancer,and an extraordinarily high incidence of lung cancer occurs in smokers suffering from Li-Fraumeni syndrome, which is characterized by germ-line inactivation of one p53 allele. In contrast, p53 mutations are infrequent in lung tumors formed in A/J mice. Moreover, despite the dominant role of cigarette smoke in the epidemiology of...
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