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Article

Lung pathology in platelet-derived growth factor transgenic mice: effects of genetic background and fibrogenic agents.

Experimental lung research - 1 Sept 2002

Li Jian, Ortiz Luis A, Hoyle Gary W

Abstract excerpt

We previously developed transgenic mice expressing human platelet-derived growth factor B chain (PDGF-B) from the lung-specific surfactant protein C (SPC) promoter. These mice developed enlarged airspaces, inflammation, and fibrosis of varying severity. In the present study we examined potential causes of this phenotypic variation and tested whether constitutive PDGF-B expression exacerbated fibrosis induced by...

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Identifiers

PMID: 12217216
DOI: 10.1080/01902140290096755

Genes

PDGFB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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