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Article

Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2007

Frick Lauren E, Delaney James C, Wong Cintyu, Drennan Catherine L, Essigmann John M

Abstract excerpt

1,N(6)-ethanoadenine (EA) forms through the reaction of adenine in DNA with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic used to combat various brain, head, and neck tumors. Previous studies of the toxic and mutagenic properties of the DNA adduct EA have been limited to in vitro experiments using mammalian polymerases and have revealed the lesion to be both miscoding and genotoxic....

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Identifiers

PMID: 17213319
DOI: 10.1073/pnas.0607377104
PMCID: PMC1783386

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