Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutator specificity of Escherichia coli alkB117 allele.

Acta biochimica Polonica - 1 Jan 2006

Nieminuszczy Jadwiga, Janion Celina, Grzesiuk Elzbieta

Abstract excerpt

The Escherichia coli AlkB protein encoded by alkB gene was recently found to repair cytotoxic DNA lesions 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) by using a novel iron-catalysed oxidative demethylation mechanism that protects the cell from the toxic effects of methylating agents. Mutation in alkB results in increased sensitivity to MMS and elevated level of MMS-induced mutations. The aim of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Escherichia coli Proteins
Share to Frameshift Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lac Operon

Share to Methyl Methanesulfonate

Share to Mixed Function Oxygenases

Share to Mutagenesis

Share to Mutagens

Source

Identifiers

PMID: 16733554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutator specificity of Escherichia coli alkB117 allele.PMID 16733554Read ↗

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage.Semantic proximity Read ↗

Evaluation of the Escherichia coli HK82 and BS87 strains as tools for AlkB studies.Semantic proximity Read ↗

The mutational specificity of two Escherichia coli dnaE antimutator alleles as determined from lacI mutation spectra.Semantic proximity Read ↗

Defective processing of methylated single-stranded DNA by E. coli AlkB mutants.Semantic proximity Read ↗

A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution.Semantic proximity Read ↗

On the identity of two bacterial mutator genes: effects of antimutagens.Semantic proximity Read ↗

AlkB dioxygenase in preventing MMS-induced mutagenesis in Escherichia coli: effect of Pol V and AlkA proteins.Semantic proximity Read ↗

Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosome.Semantic proximity Read ↗

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.Semantic proximity Read ↗

Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli: I. Frameshift mutagenesis.Semantic proximity Read ↗

Comparative potencies of induction of point mutations and genetic duplications by the methylating agents methylazoxymethanol and dimethyl sulfate in bacteria.Semantic proximity Read ↗

YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.