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Article

Protein dynamics control the progression and efficiency of the catalytic reaction cycle of the Escherichia coli DNA-repair enzyme AlkB.

The Journal of biological chemistry - 24 Oct 2014

Ergel Burçe, Gill Michelle L, Brown Lewis, Yu Bomina, Palmer Arthur G, Hunt John F

Abstract excerpt

A central goal of enzymology is to understand the physicochemical mechanisms that enable proteins to catalyze complex chemical reactions with high efficiency. Recent methodological advances enable the contribution of protein dynamics to enzyme efficiency to be explored more deeply. Here, we utilize enzymological and biophysical studies, including NMR measurements of conformational dynamics, to develop a...

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Identifiers

PMID: 25043760
DOI: 10.1074/jbc.M114.575647
PMCID: PMC4207975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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