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Article

Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53.

The Journal of biological chemistry - 22 Nov 2002

McPherson Lisa A, Loktev Alexander V, Weigel Ronald J

Abstract excerpt

The AP2 transcription factor family is a set of developmentally regulated, retinoic acid inducible genes composed of four related factors, AP2alpha, AP2beta, AP2gamma, and AP2delta. AP2 factors orchestrate a variety of cell processes including apoptosis, cell growth, and tissue differentiation during embryogenesis. In studies of primary malignancies, AP2alpha has been shown to function as a tumor suppressor in...

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PMID: 12226108
DOI: 10.1074/jbc.M208924200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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