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Article

The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression.

Cell death and differentiation - 1 Jan 2017

Lowe Julie M, Nguyen Thuy-Ai, Grimm Sara A, Gabor Kristin A, Peddada Shyamal D, Li Leping, Anderson Carl W, Resnick Michael A, Menendez Daniel, Fessler Michael B

Abstract excerpt

Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a stress-response gene that has been associated with cancer, but no studies have differentiated among or defined the regulation or function of any of its several recently described expression variants. We found that TNFAIP8 variant 2 (v2) is overexpressed in multiple human cancers, whereas other variants are commonly downregulated in cancer (v1) or minimally...

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Identifiers

PMID: 27834950
DOI: 10.1038/cdd.2016.130
PMCID: PMC5260499

Genes

TNFAIP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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