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Article

Estrogen Receptor-α Binds p53 Tumor Suppressor Protein Directly and Represses Its Function

9 Feb 2006

Abstract excerpt

Estrogen receptor-alpha (ERalpha) promotes proliferation of breast cancer cells, whereas tumor suppressor protein p53 impedes proliferation of cells with genomic damage. Whether there is a direct link between these two antagonistic pathways has remained unclear. Here we report that ERalpha binds directly to p53 and represses its function. The activation function-2 (AF-2) domain of ERalpha and the C-terminal...

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PMID: 16469747
DOI: 10.1074/jbc.c600001200

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