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Article

New insights into the expanding complexity of the tumor suppressor ASPP2

15 Sept 2009

Abstract excerpt

Apoptosis Stimulating Protein of p53-2, ASPP2, aka 53BP2L, (encoded by TP53BP2) is a pro-apoptotic member of a family of p53 binding proteins. ASPP2 expression is frequently suppressed in human cancers and numerous studies have consistently demonstrated that ASPP2 inhibits cell growth as well as stimulates apoptosis-at least in part through a p53-mediated pathway. Two independent mouse models have shown that...

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PMID: 19657229
DOI: 10.4161/cc.8.18.9474

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New insights into the expanding complexity of the tumor suppressor ASPP2PMID 19657229Read ↗

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