Salmonella pathogenicity island-2 and anticancer activity in mice.

doi:10.1038/sj.cgt.7700501

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Article

Salmonella pathogenicity island-2 and anticancer activity in mice.

Cancer gene therapy - 1 Oct 2002

Pawelek John M, Sodi Stefano, Chakraborty Ashok K, Platt James T, Miller Samuel, Holden David W, Hensel Michael, Low K Brooks

Abstract excerpt

Salmonella enterica servovar Typhimurium is capable of targeting, colonizing, and eliciting growth suppression of tumors in mice. We examined the effects of mutations on this anticancer phenotype in two Salmonella virulence gene clusters. Salmonella pathogenicity island (SPI)-1 genes promote systemic invasion from the intestine, whereas SPI-2 genes support systemic survival within macrophages and other cells....

Topics

Animals
Bacterial Proteins
CD18 Antigens
Cell Division
Female
In Vitro Techniques
Injections, Intralesional
Melanoma, Experimental
Membrane Proteins
Mice
Mice, Inbred C57BL
Mutation
Neoplasm Invasiveness
Neoplasm Transplantation
Salmonella typhimurium
Skin Neoplasms
Survival Rate

Source

Open in PubMed

Identifiers

PMID: 12224021
DOI: 10.1038/sj.cgt.7700501

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