Article
Mutations in Salmonella pathogenicity island 2 (SPI2) genes affecting transcription of SPI1 genes and resistance to antimicrobial agents.
Journal of bacteriology - 1 Sept 1998
Deiwick J, Nikolaus T, Shea J E, Gleeson C, Holden D W, Hensel M
Abstract excerpt
The Salmonella typhimurium genome contains two pathogenicity islands (SPI) with genes encoding type III secretion systems for virulence proteins. SPI1 is required for the penetration of the epithelial layer of the intestine. SPI2 is important for the subsequent proliferation of bacteria in the sp...
Topics
- Animals
- Bacterial Proteins
- Blood Bactericidal Activity
- Drug Resistance, Microbial
- Genes, Bacterial
- Gentamicins
- Humans
- Mutation
- Polymyxin B
- Rabbits
- Salmonella typhimurium
- Trans-Activators
- Transcription, Genetic
- Virulence