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Article

Mutations in Salmonella pathogenicity island 2 (SPI2) genes affecting transcription of SPI1 genes and resistance to antimicrobial agents.

Journal of bacteriology - 1 Sept 1998

Deiwick J, Nikolaus T, Shea J E, Gleeson C, Holden D W, Hensel M

Abstract excerpt

The Salmonella typhimurium genome contains two pathogenicity islands (SPI) with genes encoding type III secretion systems for virulence proteins. SPI1 is required for the penetration of the epithelial layer of the intestine. SPI2 is important for the subsequent proliferation of bacteria in the spleens of infected hosts. Although most mutations in SPI2 lead to a strong reduction of virulence, they have different...

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Identifiers

PMID: 9733677
DOI: 10.1128/JB.180.18.4775-4780.1998
PMCID: PMC107499

Genes

SPI1

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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