Article
Salmonella typhimurium strains carrying independent mutations display similar virulence phenotypes yet are controlled by distinct host defense mechanisms.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2003
Raupach Bärbel, Kurth Nicole, Pfeffer Klaus, Kaufmann Stefan H E
Abstract excerpt
The outcome of Salmonella infection in the mammalian host favors whoever succeeds best in disturbing the equilibrium between coordinate expression of bacterial (virulence) genes and host defense mechanisms. Intracellular persistence in host cells is critical for pathogenesis and disease, because Salmonella typhimurium strains defective in this property are avirulent. We examined whether similar host defense...
Topics
- Administration, Oral
- Animals
- Antigens, CD
- Immunity, Innate
- Immunocompromised Host
- Interferon-gamma
- Intracellular Fluid
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Phenotype