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Article

Functional consequences of sulfhydryl modification of the γ-aminobutyric acid transporter 1 at a single solvent-exposed cysteine residue.

The Journal of membrane biology - 1 Dec 2012

Omoto Jaison J, Maestas Matthew J, Rahnama-Vaghef Ali, Choi Ye E, Salto Gerardo, Sanchez Rachel V, Anderson Cynthia M, Eskandari Sepehr

Abstract excerpt

The aims of this study were to optimize the experimental conditions for labeling extracellularly oriented, solvent-exposed cysteine residues of γ-aminobutyric acid transporter 1 (GAT1) with the membrane-impermeant sulfhydryl reagent [2-(trimethylammonium)ethyl]methanethiosulfonate (MTSET) and to characterize the functional and pharmacological consequences of labeling on transporter steady-state and...

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Identifiers

PMID: 22918627
DOI: 10.1007/s00232-012-9492-9
PMCID: PMC3505503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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