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Article

Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking.

Methods in enzymology - 1 Jan 2010

Janovick Jo Ann, Conn P Michael

Abstract excerpt

The gonadotropin-releasing hormone (GnRH) receptor (GnRHR), because of its small size among G-protein-coupled receptors (GPCRs), is amenable to facile preparation of mutants. This receptor is used in our laboratory as a structural model for this super-family of protein receptors and has helped us understand the requirements for proper trafficking. We have demonstrated that pharmacoperones ("pharmacological...

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PMID: 21050923
DOI: 10.1016/B978-0-12-381296-4.00016-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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