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Article

Mechanisms of endoplasmic-reticulum export of glycine transporter-1 (GLYT1).

The Biochemical journal - 1 Feb 2008

Fernández-Sánchez Enrique, Díez-Guerra F Javier, Cubelos Beatriz, Giménez Cecilio, Zafra Francisco

Abstract excerpt

The GLYT1 (glycine transporter-1) regulates both glycinergic and glutamatergic neurotransmission by controlling the reuptake of glycine at synapses. Trafficking to the cell surface of GLYT1 is critical for its function. In the present paper, by using mutational analysis of the GLYT1 C-terminal domain, we identified the evolutionarily conserved motif R(575)L(576)(X(8))D(585) as being necessary for ER (endoplasmic...

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PMID: 17919119
DOI: 10.1042/BJ20070533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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