Article

Glycine receptor α3K governs mobility and conductance of L/K splice variant heteropentamers

2021-02-18

Abstract excerpt

Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain treatment and temporal lobe epilepsy. Alternative splicing into K or L variants determines the subcellular fate and function of GlyR-α3, yet it remains to be shown whether its different splice variants can functionally co-assemble, and what the properties of such hete...

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Literature Corpus work: cda02555-c9a0-50cf-8f68-dc2483eeaf66
DOI: 10.1101/2021.02.18.431627

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