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Article

An ER retention motif controls the heteromeric stoichiometry of hERG1a/1b channels.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2026

Kannan Sudharsan, Ernandez Liliana R, Robertson Gail A

Abstract excerpt

The human ether-à-go-go related gene (hERG) encodes a potassium channel essential for cardiac repolarization and neuronal excitability. In the heart, heteromeric assemblies of hERG1a and hERG1b subunits produce cardiac IKr, and mutations in either subunit are associated with long QT syndrome. Although hERG1a and 1b contain identical transmembrane and C-terminal cytosolic domains, they differ in N-terminal...

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PMID: 42611991
DOI: 10.1073/pnas.2605305123
PMCID: PMC13505996

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