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Article

Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants.

Cellular and molecular life sciences : CMLS - 5 Oct 2022

Lemmens Veerle, Thevelein Bart, Vella Yana, Kankowski Svenja, Leonhard Julia, Mizuno Hideaki, Rocha Susana, Brône Bert, Meier Jochen C, Hendrix Jelle

Abstract excerpt

Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain treatment and temporal lobe epilepsy. Alternative splicing into K or L variants determines the subcellular fate and function of GlyR-α3, yet it remains to be shown whether its different splice variants can functionally co-assemble, and what the properties of such...

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Identifiers

PMID: 36197517
DOI: 10.1007/s00018-022-04506-9
PMCID: PMC9534812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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