Article
Gene conversion-like sequence transfers between transgenic antibody V genes are independent of RAD54.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2002
D'Avirro Nicole, Truong David, Luong Michael, Kanaar Roland, Selsing Erik
Abstract excerpt
Homology-based Ig gene conversion is a major mechanism for Ab diversification in chickens and the Rad54 DNA repair protein plays an important role in this process. In mice, although gene conversion appears to be rare among endogenous Ig genes, Ab H chain transgenes undergo isotype switching and gene conversion-like sequence transfer processes that also appear to involve homologous recombination or gene...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Chickens
- DNA Helicases
- DNA Repair
- DNA Repair Enzymes
- Fungal Proteins
- Gene Conversion
- Immunoglobulin Class Switching
- Immunoglobulin Variable Region
- Mice
- Mice, Knockout
- Mice, Transgenic