Article
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
The Journal of pathology - 1 Sept 2002
Cho Nam Hoon, Cordon-Cardo Carlos, Li G C, Kim See Hyun
Abstract excerpt
The ability to repair DNA double-strand breaks is essential to maintain chromosomal stability. Virtually all soft tissue sarcomas contain chromosomal instabilities, including clonal aberrations and cytogenetic aberrations. However, the relevance of DNA-dependent protein kinase (DNA-PK) in the pathogenesis of soft tissue sarcoma has not been clarified. The main aim of this work is to compare the prognostic impact...
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