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Article

Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations.

Human pathology - 1 Jul 2009

Kim Jeung Il, Suh Jeung Tak, Choi Kyung Un, Kang Hyun Jeong, Shin Dong Hoon, Lee In Sook, Moon Tae Yong, Kim Won Taek

Abstract excerpt

The DNA-repair protein O(6)-methylguanine-DNA methyltransferase removes alkyl adducts from the O(6)-position of guanine. The adducts can mispair with T during DNA replication, resulting in a G-to-A mutation. Epigenetic inactivation of O(6)-methylguanine-DNA methyltransferase has been found in human neoplasia and is considered one of the implicated factors in chemoresistance. Sixty-two patients with soft tissue...

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Source

Identifiers

PMID: 19356788
DOI: 10.1016/j.humpath.2009.01.005

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations.PMID 19356788Read ↗

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