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Article

Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra.

The Journal of comparative neurology - 26 Aug 2002

Chu Yaping, Kompoliti Katie, Cochran Elizabeth J, Mufson Elliott J, Kordower Jeffrey H

Abstract excerpt

Nuclear receptor-related factor 1 (Nurr1), a member of the nuclear receptor superfamily, is associated with the induction of dopaminergic (DA) phenotypes in developing and mature midbrain neurons. It is well established that dopaminergic nigrostriatal function decreases with age. Whether age-related deficits in DA phenotypic markers are associated with alterations in Nurr1 expression is unknown. The present study...

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Identifiers

PMID: 12209851
DOI: 10.1002/cne.10261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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