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Article

Age-related gene expression changes in substantia nigra dopamine neurons of the rat.

Mechanisms of ageing and development - 1 Jul 2015

Parkinson Gemma M, Dayas Christopher V, Smith Doug W

Abstract excerpt

Ageing affects most, if not all, functional systems in the body. For example, the somatic motor nervous system, responsible for initiating and regulating motor output to skeletal musculature, is vulnerable to ageing. The nigrostriatal dopamine pathway is one component of this system, with deficits in dopamine signalling contributing to major motor dysfunction, as exemplified in Parkinson's disease (PD). However,...

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PMID: 26065381
DOI: 10.1016/j.mad.2015.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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