Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure.

PloS one - 3 Dec 2010

Luo Yu, Wang Yun, Kuang Serena Y, Chiang Yung-Hsiao, Hoffer Barry

Abstract excerpt

The abuse of psychostimulants, such as methamphetamine (METH), is prevalent in young adults and could lead to long-term adaptations in the midbrain dopamine system in abstinent human METH abusers. Nurr1 is a gene that is critical for the survival and maintenance of dopaminergic neurons and has been implicated in dopaminergic neuron related disorders. In this study, we examined the synergistic effects of repeated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Dopamine Plasma Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrochemistry

Share to Gene Expression Regulation

Share to Methamphetamine

Share to Nuclear Receptor Subfamily 4, Group A, Member 2

Share to Substantia Nigra

Share to Tyrosine 3-Monooxygenase

Source

Open in PubMed Open full text

Identifiers

PMID: 21151937
DOI: 10.1371/journal.pone.0015193
PMCID: PMC2997078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure.PMID 21151937Read ↗

Maternal Methamphetamine Exposure Influences Behavioral Sensitization and Nucleus Accumbens DNA Methylation in Subsequent GenerationSemantic proximity Read ↗

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene.Semantic proximity Read ↗

Alterations in amphetamine-stimulated dopamine overflow due to the Nurr1-null heterozygous genotype and postweaning isolation.Semantic proximity Read ↗

Epigenetic Effects Induced by Methamphetamine and Methamphetamine‐Dependent Oxidative StressSemantic proximity Read ↗

Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.Semantic proximity Read ↗

Neurotoxic Methamphetamine Doses Alter CDCel-1 Levels and Its Interaction with Vesicular Monoamine Transporter-2 in Rat StriatumSemantic proximity Read ↗

Mechanisms involved in the neurotoxic and cognitive effects of developmental methamphetamine exposureSemantic proximity Read ↗

Mouse strain- and age-dependent effects of binge methamphetamine on dopaminergic signaling.Semantic proximity Read ↗

NURR1-deficient mice have age- and sex-specific behavioral phenotypes.Semantic proximity Read ↗

Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use DisorderSemantic proximity Read ↗

Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra.Semantic proximity Read ↗

Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.