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Article

Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure.

PloS one - 3 Dec 2010

Luo Yu, Wang Yun, Kuang Serena Y, Chiang Yung-Hsiao, Hoffer Barry

Abstract excerpt

The abuse of psychostimulants, such as methamphetamine (METH), is prevalent in young adults and could lead to long-term adaptations in the midbrain dopamine system in abstinent human METH abusers. Nurr1 is a gene that is critical for the survival and maintenance of dopaminergic neurons and has be...

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Identifiers

PMID: 21151937
DOI: 10.1371/journal.pone.0015193
PMCID: PMC2997078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151937-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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