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Article

NURR1-deficient mice have age- and sex-specific behavioral phenotypes.

Journal of neuroscience research - 1 Sept 2022

Montarolo Francesca, Martire Serena, Chiara Francesco, Allegra Sarah, De Francia Silvia, Hoxha Eriola, Tempia Filippo, Capobianco Marco Alfonso, Bertolotto Antonio

Abstract excerpt

The transcription factor NURR1 is essential to the generation and maintenance of midbrain dopaminergic (mDA) neurons and its deregulation is involved in the development of dopamine (DA)-associated brain disorders, such as Parkinson's disease (PD). The old male NURR1 heterozygous knockout (NURR1-KO) mouse has been proposed as a model of PD due to its altered motor performance that was, however, not confirmed in a...

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Identifiers

PMID: 35593070
DOI: 10.1002/jnr.25067
PMCID: PMC9539971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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